NASA TV UFOs: 2 UFOs Filmed from the Space Shuttle
The UFO which can be seen 4 seconds into the video seems to be self-luminous, oval or disk shaped and very large. A smaller UFO which flies away from the Earth can be seen 27 seconds into the video.
The video (unknown Space Shuttle mission) comes from Martyn Stubbs’ NASA TV UFO archives:
http://www.youtube.com/watch?v=59sE2XDPWj4